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> Bergman Olle 1978 >
Age-Related Olfacto...
Age-Related Olfactory Decline is Associated with the BDNF Val66met Polymorphism : Evidence from a Population-Based Study
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- Hedner, Margareta (author)
- Stockholms universitet,Perception och psykofysik,Stockholm University, Stockholm Brain Institute
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- Nilsson, Lars-Göran (author)
- Stockholms universitet,Kognitiv psykologi,Stockholm University, Stockholm Brain Institute
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- Olofsson, Jonas K. (author)
- Stockholms universitet,Perception och psykofysik,Stockholm University, Stockholm Brain Institute
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- Bergman, Olle, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department of Pharmacology, Göteborg University, Göteborg, Sweden
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- Eriksson, Elias, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department of Pharmacology, Göteborg University, Göteborg, Sweden
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Centrum för befolkningsstudier (CBS),Institutionen för strålningsvetenskaper,Fysiologi,Department of Radiation Sciences and Integrative Medical Biology, Umeå, Sweden
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- Larsson, Maria (author)
- Stockholms universitet,Perception och psykofysik,Stockholm University, Stockholm Brain Institute
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Frontiers in Aging Neuroscience. - : Frontiers Media SA. - 1663-4365. ; 2:7, s. 24-
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Abstract
Subject headings
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- The present study investigates the effect of the brain-derived neurotrophic factor (BDNF) val66met polymorphism on change in olfactory function in a large scale, longitudinal population-based sample (n = 836). The subjects were tested on a 13 item force-choice odor identification test on two test occasions over a 5-year-interval. Sex, education, health-related factors, and semantic ability were controlled for in the statistical analyses. Results showed an interaction effect of age and BDNF val66met on olfactory change, such that the magnitude of olfactory decline in the older age cohort (70–90years old at baseline) was larger for the val homozygote carriers than for the met carriers. The older met carriers did not display larger age-related decline in olfactory function compared to the younger group. The BDNF val66met polymorphism did not affect the rate of decline in the younger age cohort (45–65years). The findings are discussed in the light of the proposed roles of BDNF in neural development and maintenance.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- brain-derived neurotrophic factor
- val66met
- olfaction
- odor identification
- aging
- Psychology
- Psykologi
- psykologi
- Psychology
- brain-derived neurotrophic factor
- val66met
- olfaction
- odor identification
- aging
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hedner, Margaret ...
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Nilsson, Lars-Gö ...
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Olofsson, Jonas ...
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Bergman, Olle, 1 ...
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Eriksson, Elias, ...
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Nyberg, Lars, 19 ...
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Larsson, Maria
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- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Frontiers in Agi ...
- By the university
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Stockholm University
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Umeå University
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University of Gothenburg